
Infernus vs Vyper

Infernus win rate52.8%127k games
Same lane53.3%46k games
Updated 2026-11-03 18:42 UTC · all ranks, shrunk toward 50% by sample size
Playing against Vyper
Their combo: Vyper poisons you with Lethal Venom, petrifies you for 2.2s with Petrifying Bola (the venom ignores the petrify’s damage block), then bursts you when it ends.
When to fight: Petrifying Bola is on a 115s cooldown. Once it’s used, commit.
Beware: Stay outside its 12m radius. Lethal Venom hits hardest below 30% health, and Slither tier 3 gives her a 180 barrier on slides.
Items for Infernus against Vyper
Intensifying Magazine+1.0 pp · 53.7% vs Vyper · usually 49.5%
Split Shot+0.8 pp · 52.5% vs Vyper · usually 48.4%
Restorative Shot+0.6 pp · 53.0% vs Vyper · usually 49.2%
Healing Nova+0.6 pp · 54.0% vs Vyper · usually 50.1%
Close Quarters+0.6 pp · 52.4% vs Vyper · usually 48.5%
Melee Lifesteal+0.6 pp · 52.6% vs Vyper · usually 48.8%
Healing Rite+0.6 pp · 52.8% vs Vyper · usually 49.0%
Bullet Lifesteal+0.5 pp · 54.7% vs Vyper · usually 50.9%
Lift: how much better the item does in matches against Vyper than it usually does, compared with other items against Vyper. Only items Infernus players commonly build are shown.